ARUK Dementia Research Event, University of Bradford, Thursday, 20. June 2019

Academics from the University of Bradford (UoB) invite health professionals, carers, patients and members of the public to join us at this event where they can learn more about the latest research into the detection and treatment of dementia, including Alzheimer’s disease, and share their own experiences.
The event on Thursday 20 June is open to all, free to attend and will provide an overview of some of the latest research, with attendees having the opportunity to ask questions to leading experts from the University of Bradford, York Teaching Hospitals NHS Trust, and Alzheimer’s Research UK.

From 15.30: Registration
16.00: Welcome - Dr Ritchie Williamson, UoB
16.05: Alzheimer's Research UK – Introduction
16.15: Prof Gail Mountain - 'Psychosocial Dementia Research' (plus Q&A)
16.55: Break and refreshments
17.15: Dr Ritchie WIlliamson - ‘Current Clinical Trials and Therapeutic Opportunities’ (plus Q&A)
17.50 Mr Clive Nicholcon - 'Joint Dementia Research Programme'  (plus Q&A)
18.15 : Closing remarks

If you require any further information about the event, please contact:
Tel: 01274 236073

Prof Gail Mountain
Professor of Applied Dementia Research, Director of the Centre for Applied Dementia Studies
Gail Mountain is Professor of Applied Dementia Research and Director of the Centre for Applied Dementia Studies. Gail is also an occupational therapist; having practiced for 13 years before becoming involved in research.
Gail’s research interests are focussed upon improving the quality of life of older people through provision of appropriate interventions, good design and by facilitating participation, reflecting her occupational therapy background. She also has significant expertise in research impact, having previously led a programme of impact activities for the EPSRC.
Dementia is a longstanding clinical and research interest; Gail is currently leading a 12 site NIHR HTA trial to examine the clinical and cost effectiveness of a multi component psychosocial intervention for people with early dementia. She is co-applicant for the NIHR/ ESRC Promoting Independence in Dementia research programme which involves development and evaluation of a brief intervention for people with dementia following diagnosis and also for the NIHR HTA funded Finch study which is examining the effectiveness of a falls intervention programme in care homes. Gail remains interested in how new technologies might assist people to live well with dementia and how outcome measures need to change to enable people with dementia to report positive experiences in the moment.

Dr Ritchie WIlliamson
Lecturer in Therapeutics, University of Bradford
Ritchie's research focuses on identifying molecular mechanisms that underlie age-related cognitive decline and dementia. Increasing data from observational studies has identified a number of potentially modifiable risk factors associated with an increased risk of developing dementia including diabetes, obesity, physical inactivity, low educational attainment, depression, smoking, and hypertension. In addition, these risk factors are additive suggesting that common signaling pathways underlie these risk factors. A key observation of a number of these risk factors is that they display alterations in energy intake/expenditure and glucose metabolism.
It has previously been established that there is a link between altered energy intake, insulin sensitivity and poor cognitive performance. However, the precise molecular mechanisms that underlies the observed decrease in cognitive performance remains to be established. One possible mechanism is protein O-GlcNAcylation (a glucose-dependent post translational modification). Protein O-GlcNAcylation is altered in Alzheimer’s disease.
Other than a well-established role in gene expression, how protein O-GlcNAcylation effects protein function is still to be fully determined. Work in my laboratory aims to elucidate the links between glucose-dependent alterations in protein modifications, nutritional status, and ageing to molecular mechanisms underlying dementia.

Mr Clive Nicholson
Senior Senior Research Nurse at the NIHR Clinical Research Network Yorkshire and Humber
Clive is based at York Teaching Hospitals NHS Trust, and his main focus is the Join Dementia Research programme. Clive has been involved in clincal research since 1992 and has been with the Joint Dementia Research porgramme since 2015. The National Institute for Health Research, in partnership with Alzheimer Scotland, Alzheimer's Research UK and Alzheimer's Society have developed Join Dementia Research (JDR), a service which allows people to register their interest in participating in dementia research and be matched to suitable studies. Clive is the JDR lead for Yorkshire and Humber region.

Thursday, 20. June 2019, University of Bradford, ARUK Dementia Research Event

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